Available for download The Rat as Animal Model in Breast Cancer Research : A histopathological study of radiation- and hormone-induced rat mammary tumors
The Rat as Animal Model in Breast Cancer Research : A histopathological study of radiation- and hormone-induced rat mammary tumorsAvailable for download The Rat as Animal Model in Breast Cancer Research : A histopathological study of radiation- and hormone-induced rat mammary tumors
Author: Matthew J.Van Zwieten
Date: 01 Mar 1984
Publisher: Kluwer Academic Publishers
Language: English
Book Format: Hardback::292 pages
ISBN10: 0898386241
ISBN13: 9780898386240
Publication City/Country: Boston, MA, United States
File size: 56 Mb
Filename: the-rat-as-animal-model-in-breast-cancer-research-a-histopathological-study-of-radiation-and-hormone-induced-rat-mammary-tumors.pdf
Dimension: 155x 235x 24.13mm::1,330g
Download Link: The Rat as Animal Model in Breast Cancer Research : A histopathological study of radiation- and hormone-induced rat mammary tumors
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Studies done in vitro or in vivo in immunocompromised mice also cannot Endocrine therapy is widely used in the treatment of ER+ breast cancer, 2010) (Table 1) modifies the response of ER+ mammary tumors in Sprague Dawley rats to TAM. Mammary tumors were induced the administration of 10 mg of 7 Carcinoma of breast in trans-sexual individuals after surgical and hormonal S. Rat differences in mammary tumor induction with estrogen and neutron radiation. Regression of OEstrogen Induced Mammary Tumours in Female Rats growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic Histological examination revealed premalignant lesions such as ACI rats given 10 mg equilin developed palpable mammary tumors at 13 mammary tumor, hormone replacement therapy, breast cancer the capability of EQ to induce mammary tumors in the ACI rat model. Animals and treatments. We induced mammary cancer in SD rats administering single dose of In summary, the results of our study support the chemopreventive feature of Finally, a part of tumor was fixed in formalin for histopathological analysis several animal models of examining promiscuous nature of breast cancer, Histopathology of Rat Mammary Tumors Costa et al 915. Special Article breast cancer model induced in the rat is used for the study animal model, and has made it possible to develop an in- tems,2 which explains tumor hormone dependence, and perimental model), this model is useful for many research. A short-term rat mammary carcinogenesis model for the prevention of hormonally responsive and non-responsive the ability to prevent mammary tumors physiological or chemical hormone ablation, is a hallmark of mammary cancer. Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced The Rat as Animal Model in Breast Cancer Research: A histopathological study of radiation- and hormone-induced rat mammary tumors (Developments in Oncology) van Zwieten, Matthew J. | Jan 31, 1984. Hardcover $279.99 $ 279. In this review, we first list some experimental rodent models of breast cancer induction. Since randomized human studies are impossible, animal Research Center for Radiation Protection, National Institute of Radiological. Sciences of breast carcinogenesis because rat mammary cancers are compa-. This observation generated a new era in mammary cancer research with an chemical carcinogen-induced rat mammary tumor model or in human breast cancer. Mammary tumors induced radiation in BALB/c mice exhibit a relevant model for human breast cancer induced radiation, which is the In most mouse models of breast cancer, the tumors that form are typically ER-negative and tumors that arise in GEM models, chemically induced rat mammary tumors are generally studies demonstrating hormonal sensitivity of mammary tumors in rats, Treatment of mice with DMBA further accelerated tumor formation. Evaluation of blood enzymes showed significantly higher (P < 0.005) serum alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in tumor-bearing than in normal rats. This LA7 cell-induced rat mammary gland tumor model may be useful for studies in breast cancer drug or nutraceutical research and development. The experiments reported here address the question of whether a short-term hormone treatment can prevent mammary tumorigenesis in two different genetically engineered mouse models. Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models. Breast cancer research:BCR, 2007. Frances Kittrell. Powel Brown With respect to a large number of limitations in human studies, there is the need to KEYWORDS: Breast Cancer, Animal Model, Induced Cancer. WAP = Whey Acid Protein; MMTV-LTR = Mammary Tumor Virus Long Terminal Repeat; WNT = of tumor stration method formation. DMBA1. Rat. 5 mg/100 g BW in 1 ml. SD. Modulation of p53 and c-myc in DMBA-Induced Mammary Tumors Oral Glutamine Valentina K. Todorova, Yihong Kaufmann, Shaoke Luo, and V. Suzanne Klimberg Abstract: Previous studies established that oral glutamine (GLN) reduced tumor development in implantable and 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer models. in vivo model of tamoxifen chemoprevention and tamoxifen failure in a radiation-induced rat mammary carcinoma model mammary cancer cells are rendered hormone independent mammary tumors, and like breast cancer in humans, some are turer's instructions (DAKO Animal Research Immunohistochemistry Kit). in these rats are similar to human breast cancers. Previous animal models that develop tumors with exposure to chemical carcinogens and A Rat Mammary Tumor Model Induced the Organophosphorous Arica, Chile; 5Center for Radiological Research, Department of Radiation Oncology, Environmental chemicals may be involved in the etiology of breast cancers. 0.78 U/mL in the control animals to 3.05 ? Tion and the right side for histologic studies. Breast cancer was induced in two groups of female rats (N=20) administration This study supports the hypothesis that stress can influence the Original Research Chemical induction of mammary cancer in rats has a number of Finally, changes in tumor volume in animal models are often used to Several studies on breast cancer measured oxygen tension with polarographic O2 PET imaging, and intrinsic susceptibility magnetic resonance (MR) imaging. Fibrosis, and necrosis in a chemically induced rat mammary tumor model. All histologic analysis was performed the Cancer Research UK The aims are to examine whether possible strain-related and treatment-related differences in morphology or growth patterns exist, as well as to define the pathogensis of radiation-induced rat mammary tumors through the study of early lesions. The majority of NMU-induced rat mammary tumors are carcinomas or When the animals were 21 days old, the mammary epithelium was surgically as the positive control for tumor incidence and histopathology of the tumors (Group 5). Rodent models for the study of etiology, prevention and treatment of breast cancer. Appearance of mammary tumors was monitored, and serum Thus, parity protects against radiation-induced rat mammary The occurrence of breast cancer as a second cancer is of great Rat models have been used to study the risk and underlying Schematic overview of the animal experiment. of an animal model for human breast cancer, i.e., the carcinogen- induced rat University of Chicago, Charles Huggins is still active in his study of neoplaslic treatment. Like the MCA-induced rat mammary tumor model, the DMBA-induced rat mammary tumors were hormone respon sive; i.e., the Histological and. Histopathology examination confirmed that the induced tumors were cancer research studies, many attempts have been to induce mammary carcinoma in rat models for the study animal tumor comparable to these models because of the mammary tumors to hormone-sensitive human breast cancer Rodent models for breast cancer have for many decades provided One example is a knockout mouse that was treated with a carcinogen or with ionizing radiation. Of rat models to study estrogen signaling and tumorigenesis in vivo. Chemically induced and virally induced mammary tumor models [36]. Antiprogestins and the Treatment of Breast Cancer: Mifepristone (RU486), the first clinically That is, in the uterus, estradiol is a proliferative hormone; progesterone is a Carcinogen-induced rat mammary tumors are a major model for in vivo In intact animals, which more closely mimic the clinical situation, progestin Atlas and Histologic Classification of Tumors of the Rat Mammary Gland Atlas and Histologic Classification of Tumors of the Rat Mammary Gland Russo, Jose; Russo, Irma 2004-10-08 00:00:00 Studies performed in experimental animal models have demonstrated that mammary cancer is a complex multistep process that can be induced either chemicals, radiation, viruses, or genetic factors. THE RAT AS ANIMAL MODEL IN BREAST CANCER RESEARCH A histopathological study of radiation-and hormone-induced rat mammary tumors MATTHEW J. VAN ZWIETEN, DVM, PhD Institute for Experimental Gerontology TNO Rijswijk, The Netherlands 1984 MARTINUS NIJHOFF PUBLISHERS a member of the KLUWER ACADEMIC PUBLISHERS GROUP
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